Figure 3

Figure 3

Scfd1 deficiency leads to cardiac dysfunction in zebrafish embryos. Survival, heart rate, ventricular end-diastolic area (EDA) and fractional area change (FAC) are reduced in embryonic hah^vcc43−/− and scfd1^vcc44−/− mutants, while heterozygous siblings of both lines (+/−) are indistinguishable from wildtype (WT; +/+). Non-parametric survival test (Cox-Mantel) and two-way ANOVA p-values stated. Animal numbers, mean values, and multiple comparison p-values for all variables, time points, and genotypes listed in Supplementary Table S2; asterisk indicates significant differences from WT in hah^{vcc4 −/−} and scfd1^vcc44−/− mutants. Significance if p < 0.05. Created with BioRender.com.