Fig 3

Fig 3 Chimeric subunits between the δ and the ε subunits.

(A), 3D structure of nAChR. The extracellular domain, the transmembrane domain and the intracellular domain are shown in cyan, green and magenta, respectively. Two bungarotoxin (BTX) molecules, shown in red, bind to the extracellular domain (PDB ID; 6uwz) [20]. (B), Schema of chimeras generated in this study. “OUT”, “TM”, “IN” represent the extracellular, transmembrane and intracellular domain, respectively. (C), Definition of the extracellular, transmembrane and intercellular domain in this study. Amino acid alignments of the upper lines and the lower lines are the δ and ε subunits, respectively. Cyan, green, magenta lines indicate the extracellular, the transmembrane and the intracellular domains, respectively.