Fig 1

Fig 1 Inhibition of the nAChR current by pancuronium.

(A), Pentameric combination of zebrafish nAChR subunits. (B), Representative current traces of the ε-type (upper panels) and the δ-type (lower panels) elicited by 100 μM ACh in the presence of 0, 0.01, 0.1, 1 μM pancuronium, from left to right. Currents from the same oocytes are shown, respectively. Holding potential was -80 mV. Bars at the top of the traces indicate the timing of the 100 μM ACh application. (C), Dose-dependent inhibition of the ε-type and the δ-type. Data points are shown as mean ± sem. (N = 5 for the ε-type, N = 6 for the δ-type). (D), IC₅₀s for the ε-type and the δ-type against pancuronium. Dots and bars indicate individual IC₅₀ values and means, respectively. Error bars show standard errors.