Fig. 4 MM-201 does not alter the bactericidal activity of gentamicin, kanamycin, or neomycin as measured by the Kirby-Bauer Assay. (A) Co-treatment with one of a range of MM-201 concentrations (100 pM-10 µM) does not alter the area of inhibited E. coli growth surrounding the treatment-soaked disk (Two-way ANOVA; MM-201: F6, 139=0.7523 p = 0.6086). (B) MM-201 does not alter bactericidal activity of gentamicin, kanamycin, or neomycin against S. aureus (Two-way ANOVA; MM-201: F6,56=0.5474 p = 0.7699). (C) MM-201 does not alter bactericidal activity of gentamicin against P. aeruginosa (Two-way ANOVA; MM-201: F6,28=0.7975 p = 0.5800). N = 6 disks per treatment, and error bars represent + s.d.
Reprinted from Hearing Research, 434, Uribe, P.M., Hudson, A.M., Lockard, G., Jiang, M., Harding, J., Steyger, P.S., Coffin, A.B., Hepatocyte growth factor mimetic confers protection from aminoglycoside-induced hair cell death in vitro, 108786108786, Copyright (2023) with permission from Elsevier. Full text @ Hear. Res.