ZFIN Image: Uribe et al., 2023, Fig. 3

Image

Figure Caption

Fig. 3 MM-201 mediated protection is dependent on mTOR signaling. (A-D) Representative images of (A) untreated, (B) 2 mM neomycin, (C) 2 mM neomycin plus 1 pM MM-201, or (D) 2 mM neomycin plus 1 pM MM-201 and 10 µM rapamycin-treated utricles. (E) Protection from neomycin conferred by 1 pM MM-201 is attenuated with co-treatment of the mTOR inhibitor rapamycin (One-way ANOVA: F_3,7 = 12.56 p = 0.0033). Asterisks indicate significant difference between the 2 mM neomycin plus 1 pM MM-201 group and the 2 mM neomycin plus 1 pM MM-201 and 10 µM rapamycin group (**p<0.01). N = 2–3 utricular explants per treatment and error bars represent + s.d.

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Reprinted from Hearing Research, 434, Uribe, P.M., Hudson, A.M., Lockard, G., Jiang, M., Harding, J., Steyger, P.S., Coffin, A.B., Hepatocyte growth factor mimetic confers protection from aminoglycoside-induced hair cell death in vitro, 108786108786, Copyright (2023) with permission from Elsevier. Full text @ Hear. Res.