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FIGURE 8
Representative images of SMI-treated zebrafish embryos after 48 h of incubation. Treatment of zebrafish embryos with G2-1, G2-4 and G2-6 showed increasingly severe cardiac malfunctions with increasing compound concentrations. The SMIs G2-2 and G2-3 induced necrosis at concentrations of 40 or 20 μM, respectively. Arrow indicates blood congestion and resulting cardiac edema (n = 20 for each compound).
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