FIGURE 3

FIGURE 3

Overview over the amino acid sequence conservation of the human and zebrafish CK1 variants. Alignments between human CK1 and the zebrafish CK1 variants were performed using PRALINE multiple sequence alignment (Centre for Integrative Bioinformatics VU, see also Supplementary Figure S1). Based on the alignment, the figure shows the conservation of certain amino acids indicated by the red bars below. There is a very high conservation visible in the N-terminal and kinase domains whereas the C-terminal region shows more variability (A) Alignment between human CK1δ (hCK1δ) and zebrafish CK1δA and B (DrCK1δA and DrCK1δB). (B) Alignment between human CK1ε (hCK1ε) and zebrafish CK1ε (DrCK1ε).