ZFIN Image: Cannone et al., 2023, Figure 7

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Figure Caption

Figure 7

Transmission electron micrographs of no-injected (A,B) or injected with vehicle (C,D), hMYOT WT (E,F), hCRYAB WT (G,H), hMYOT S95I (I,J), hCRYAB G154S (K,L). In non-injected wildtype embryos or injected embryos with vehicle or wildtype genes muscle fibers show normal sarcomere structure with highly organized and well-aligned thick and thin myofilaments flanked by Z-disks. By contrast, embryos injected with hMYOT S95I sarcomeres showed abnormalities of Z-disk (black arrowheads in panel (J)), which appears irregular with its extension into I band. Large areas depleted of myofilaments, stressed fiber-like structures (black asterisk in panel (K)) and reduced density of the sarcomeric myofilaments were observed in myofibers of hCRYAB G154S injected embryos. Scale bar, 200 nm.

Acknowledgments

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