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Fig. 6 Functionally similar molecules evoke similar behavioral responses
(A) Neuroactive compounds with similar annotated functions elicit similar behavioral fingerprints.
(B) Behavioral fingerprints of functionally similar molecules are consolidated to a single behavioral fingerprint by calculating the median value of each behavioral category, and the resulting behavior fingerprints are hierarchically clustered. Only groups of drugs containing no less than 3 compounds sharing the same annotated function are included in the analysis. The group labels are colored by the targeted pathway. Black arrows point to behavioral fingerprints of dopamine D1, D2, and D3 receptor agonists, respectively.