Figure 6

Figure 6

cep290 and bbs2 mutant gene expression as compared to a regeneration time series. (A) Differentially expressed genes across a 28-day retinal regeneration versus expression in cep290 and bbs2 versus wild-type. Expression in the mutants did not reach the levels seen between 24 h post-lesion and 5 days post-lesion and was most comparable to animals 10–28 days post-lesion. (B) 179 of the DEGs shared between cep290 and bbs2 were also differentially expressed between 24 and 72 h post-lesion, and the expression of these genes closely paralleled that of the actively regenerating animals.