Fig. 6

Fig. 6

The effects of chronic treatment with VPA, TC-G 1008, or ZnCl₂ on PTZ-induced epileptogenesis in Swiss Albino mice. a VPA (150 mg/kg), TC-G 1008 (10 mg/kg), ZnCl₂ (8 mg Zn/kg), or VEH were injected i.p. once daily on alternate days during weekdays. 30 min later, PTZ (40 mg/kg) was injected i.p. Immediately after each PTZ injection, the mice were subjected to an evaluation of behavioral seizures, which lasted 30 min. The total number of PTZ injections was 19. Data are expressed as means ± SEM of seizure severity after each injection (b) and the percentage of mice displaying consecutive stage 5 seizures (fully kindled mice) after the last PTZ injection (c). n = 15 in each group. p values were determined by two-way repeated measures ANOVA and Dunnett’s multiple comparison test or Fisher’s exact test. *p < 0.05, **p < 0.01