Fig. 4

Fig. 4

The effects of single doses of TC-G 1008 (b–d) or ZnCl₂ (e–g) on acute seizures induced by kainic acid (KA). a Drugs or VEH were administered i.p. in Swiss Albino mice. 30 min later, KA (40 mg/kg, i.p.) was administered. Immediately after KA administration, the mice were subjected to an evaluation of behavioral seizures for 2 h. b–g The doses of drugs are shown on x-axes in mg/kg. Data are expressed as means ± SEM of seizure severity or latency to scratching and the percentage of animals displaying stage 7 characteristics (SE/death). Latency to scratching was impossible to measure in mice that received 8 mg Zn/kg because they proceeded immediately to advanced seizure stages. b–d n = 10 VEH, n = 10 TC-G 1008 10, n = 9 TC-G 1008 20, n = 8 TC-G 1008 40. e–g n = 10 VEH, n = 10 Zn 2, n = 10 Zn 4, n = 12 Zn 8. p values were determined by one-way ANOVA and Bonferroni’s multiple comparison test or the Chi-square test. *p < 0.05, **p < 0.01