Fig. 5

Fig. 5

Local field potential (LFP) recordings from the optic tectum of zebrafish larvae exposed to TC-G 1008 (b–d) or ZnCl₂ (e–g) and pentylenetetrazole (PTZ). a Zebrafish larvae were incubated with TC-G 1008 (70 µM), ZnCl₂ (65 µM) (at maximally tolerated concentrations, MTCs) or VEH for 20 h and subsequently exposed to PTZ (20 mM) or VEH for 5 min. The LFP recordings began 5 min after removing the larva from VEH/PTZ solution and lasted 20 min. b–g Results are expressed as means ± SEM of the number of epileptiform-like events, the cumulative duration of epileptiform-like events, and the mean duration of epileptiform-like events. b–d n = 10 VEH VEH, n = 8 VEH PTZ, n = 5 TC-G 1008 VEH, n = 14 TC-G 1008 PTZ. e–g n = 10 VEH VEH, n = 8 VEH PTZ, n = 7 Zn VEH, n = 17 Zn PTZ. p values were determined by one-way ANOVA and Bonferroni’s multiple comparison test. *p < 0.05, **p < 0.01, ***p < 0.001