ZFIN Image: Eyal et al., 2022, Fig. 4

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Figure Caption

Fig. 4

Biogenic plate-like guanine crystals form via templated nucleation of (100) crystal leaflets on preassembled protein fibers. (A-E) CryoET reconstructions of iridophores isolated from zebrafish larvae at different maturation stages. Scale bars are 100 nm. (A) An early iridosome showing a scaffold of parallel protein fibers. (B) A more developed iridosome, in which the initial nucleation of (100) crystal leaflet on a protein scaffold is taking place. (C) Several individual leaflets, imaged edge-on, with their (100) crystal plane parallel to each other. (D) The leaflets have almost completely coalesced into a single crystal. (E) A mature iridosome, where the leaflets have completely merged into a single crystal. (F) Schematic illustration of the proposed crystallization mechanism.

Acknowledgments

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