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Fig. 3 Top altered regulators and functions in zebrafish exposed to 400 ppb PFBA during embryogenesis. The top regulators and functions are primarily associated with lipid pathways. Rectangles represent ligand-dependent nuclear receptor, hexagons represent function, ovals represent transcription regulator, and circles represent other molecules. Blue indicates predicted inhibition and orange indicates predicted activation. Lines with arrows indicate activation and lines without arrows indicate inhibition. A solid line indicates direct interaction and a dashed line indicates indirect interaction. A dotted line indicates that the association is predicated but not confirmed in literature.