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Figure 6

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ZDB-IMAGE-230501-153
Publication
Pose-Méndez et al., 2023 - Lifelong regeneration of cerebellar Purkinje cells after induced cell ablation in zebrafish
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Figure 6

Monitoring of the Purkinje cell (PC) layer after induced PC ablation in adults.

(A) In vivo stereomicroscopy showing tagRFP-T fluorescence in the PC layer, and illustration of the time course of fluorescence recovery after PC ablation in adults (at 5 mpf) monitored until 1 ypt. Representative confocal images of whole mount cerebelli from dorsal view (B–E) and sagittal vibratome sections after immunostaining with the antibodies anti-tagRFP and anti-ZebrinII (F–K), comparing the cerebellum in ablated fish (endoxifen treated; C–E, F–H) vs control group (dimethyl sulfoxide [DMSO] treated; B, I–K). Arrows in C, F point out apoptotic bodies. Equivalent results were observed in two additional independent ablations in adult cerebelli (data not shown).

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