ZFIN Image: Hasegawa et al., 2023, Figure 4

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Figure Caption

Figure 4

DOXO-induced cardiotoxicity in zebrafish embryos following manual or pronase dechorionation. (A–J) 96 hpf larvae that were treated from 24 hpf with (A,B,E,F) DMSO or (C,D,G–J) DOXO. Lateral views of larvae show anterior to the left. (E–J) Magnifications of head and cardiac region show paired brightfield and fluorescent images. Black arrows in (C,D,G,J) point to swelling around the heart. In (F,H,J), myl7-gfp (green) labels the myocardium, which is reduced in DOXO treatment ((H,J), white arrows). (K) Graph of % larvae showing cardiac edema. n = 4 treatment replicates, each consisting of eight embryos. ns = not significant.

Acknowledgments

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