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Fig. 12 Effects of sp5a and sp5l knockdown on early prosensory development. (A–H) Dorsal views (medial to the top, anterior to the left) of otic tissue showing expression of atoh1b at 12 and 14 hpf in wild-type control embryos, pax2a−/− mutants, sp5a−/−; sp5l−/− double mutants, and pax2a−/−; sp5a−/−; sp5l−/− triple mutants. Scale bar (A), 50 μm. (I–P) Dorsal views (anterior to left) showing expression of atoh1b at 12 and 14 hpf following injection of sp5a-MO and/or sp5l-MO at the one-cell stage, as indicated at the top.
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Reprinted from Developmental Biology, 492, Tan, A.L., Mohanty, S., Guo, J., Lekven, A.C., Riley, B.B., Pax2a, Sp5a and Sp5l act downstream of Fgf and Wnt to coordinate sensory-neural patterning in the inner ear, 139-153, Copyright (2022) with permission from Elsevier. Full text @ Dev. Biol.