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Fig. 7 Effects of BIO on pax2a expression and otic patterning in pax2a mutants. (A) Cross sections (dorsal to the top, medial to the left) showing expression of pax2a at the indicated times in controls and embryos treated with BIO from 12 hpf. (B) Dorsolateral views showing expression of otic markers (as indicated on the left) at 24 hpf after incubation with DMSO (control) or BIO from 12 hpf as indicated at the top. Black arrowheads (Ba, Bb) show regions where sp5a expression is downregulated relative to wild-type embryos. Ectopic expression (e) of atoh1a is indicated (Bc, Bd). Scale bar, 50 μm.
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Reprinted from Developmental Biology, 492, Tan, A.L., Mohanty, S., Guo, J., Lekven, A.C., Riley, B.B., Pax2a, Sp5a and Sp5l act downstream of Fgf and Wnt to coordinate sensory-neural patterning in the inner ear, 139-153, Copyright (2022) with permission from Elsevier. Full text @ Dev. Biol.