Fig. 7

Fig. 7

Fig. 7. Diagram of macrophage behavioural switch during wound healing Macrophage behavioural changes during wound healing highlighting 3 different migration modes, velocity changes and shape changes at indicated time points after amputation. First, macrophages undergo a directional migration, with high velocity, followed with accumulation of macrophages at the wound, having low velocity and amoeboid shape. Second macrophages undergo a reverse migration, with the opposite directionality compared to the first phase, occurring between 9 and 13 hpA. This phase also includes increase of velocity and shape changes towards branched, elongated morphology and it is regulated by LOX activity. The third phase is circular migration using mesenchymal mode, with constant high velocity and branched, elongated shape, lasting till the end of wound repair.