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Fig. 4.
PI3K/AKT mutant clones induce a heterochronic shift in long bone development. (A) Schematic representation and in vivo confocal imaging of first cartilage anlagen [marked by Tg(sox10:DsRed) (magenta)] in caudal, anal and dorsal fins. (B-D) In vivo confocal imaging of chondrocytes [Tg(sox10:DsRed) (magenta)] at SL 4 mm in GFP (green) (B), akt1E18K-GFP (green) (C) and myr-p110-GFP (green) (D) mosaic larvae reveals premature formation of cartilage anlagen in median fins of akt1E18K-GFP and myr-p110-GFP larvae. SL, standard length in mm. Scale bars: 50 μm.
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