ZFIN Image: Hanot et al., 2023, Figure 1

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Figure Caption

Figure 1

The mammalian Polycomb repressive complexes. (A) PRC2 is composed of four core subunits, EZH1/2, EED, SUZ12 and RBBP4/7, and is classified as two distinct complexes, PRC2.1 and PRC2.2 based on the auxiliary proteins associated. (B) The core PRC1 complex is composed of RING1 or RNF2 associated with one of the six PCGF proteins. Canonical PRC1 (cPRC1) includes PCGF2 or BMI1 (PCGF4), one of the chromobox proteins (CBX2, CBX4, CBX6-8), a polyhomeotic protein (PHC1/2/3) and eventually an SCM protein (SCMH1 or SCML1/2/3). In contrast, non-canonical PRC1 (ncPRC1) can include all PCGF proteins (PCGF1/2/3/4/5/6) associated with RYBP or YAF2. The identity of the PCGF subunit imposes the nature of the auxiliary proteins present in the assembly, thus defining diverse distinct ncPRC1 complexes.

Acknowledgments

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