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Fig 5
Loss of FIXb impairs clot formation in f3a-null offspring.
(A) Loss of f9b does not influence induced venous occlusion in A*/bb but does decrease total frequency of occlusion in aa/B* larvae at 3 dpf. (B) Loss of f9b does not significantly affect clot formation in A*/bb offspring. In aa/B* larvae, loss of f9b leads to a significant impairment of occlusive clot formation. Statistical significance by Mann-Whitney U testing: ** < 0.01. A* represents AA or Aa, B* represents BB or Bb. (C) Summary of data in (A) and (B) with proposed relative ohnolog occlusive activity in the presence and absence of FIX, in arterial versus venous systems.
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