ZFIN Image: Truong et al., 2020, Fig. 1

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Figure Caption

Fig. 1

Dot-heatmap representation of the developmental toxicity for 61 FRCs.

Dechorionated embryos were exposed to 61 FRCs to 4 dosing regimens from 6 to 120 hpf. The size of the dots represents potency, with the bigger circles representing a lower concentration; color dots represent morphological endpoints (red), while neurobehavioral endpoints are represented as yellow (hyperactivity) and blue (hypoactivity). The lowest effect concentration was computed for each endpoint in the morphology, 24h (24 hpf photomotor response), and 5d (120 hpf larval photomotor response) behavioral assays. For morphology, summary endpoints were created: any 24hr sublethal effect (any24h.MO24−), any 24 hr effect (any24h.MO24+), any 120 hpf sublethal effects (any.5d.MORT−), any 120 effects (any.5d.MORT+), any sublethal effects (any.MO−) and any effect throughout the exposure (any.MO+). The 24 hr behavioral assay detects motion in 3 intervals, Background, Excitatory, and Refractory, and a summary endpoint (all). At 5d, the behavioral assay measures distance traveled in the visible light phase and the dark (infrared) phase, and overall movement (All).

Acknowledgments

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Reprinted from Reproductive toxicology (Elmsford, N.Y.), 96, Truong, L., Marvel, S., Reif, D.M., Thomas, D., Pande, P., Dasgupta, S., Simonich, M.T., Waters, K.M., Tanguay, R.L., The multi-dimensional embryonic zebrafish platform predicts flame retardant bioactivity, 359-369, Copyright (2020) with permission from Elsevier. Full text @ Reprod. Toxicol.