IMAGE

Fig. 5

ID
ZDB-IMAGE-221212-5
Source
Figures for Lu et al., 2021
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Figure Caption

Fig. 5

Figure 5. The binding mode analysis of DC-TEAD3in03. (A) Binding mode of DC-TEADin1072 (magenta) with TEADs protein (TEAD1: 6IM539, TEAD2: 5EMV30, TEAD3: 5EMW30, TEAD4: 3JUA40). DC-TEADin1072 forms clash (red dash) with Leu383 in TEAD2 and Leu366 in TEAD4, rationalizing the selectivity towards TEAD1 and TEAD3. (B) Binding mode of DC-TEAD3in01 with TEAD3. (C) Binding mode of DC-TEAD3in02 with TEAD3. (D) Binding mode of DC-TEAD3in03 with TEAD3. (E) The clash (red dash) between DC-TEAD3in03 (orange) and TEAD2, TEAD4. (F) Overlap mode of DC-TEADin1072 (cyan) and DC-TEAD3in03 (salmon) with TEAD3.

Acknowledgments
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