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Fig. 3 Figure 3. Biochemical and biophysical methods demonstrated the direct binding of DC-TEADin1072. (A) TEAD3 thermal shift assays. Synthetic YAP peptide was used as the positive control with the ratio of 1:5. The experiments were performed in biological triplicates. (B) The shift of Tm values of TEAD3-YBD WT and TEAD3-YBD mutants with DC-TEADin1072. (C) and (D) The alignment of DC-TEADin1072 (green) with myristic acid (salmon) (PDB code: 5OAQ)38 and flufenamic acid (grey) (PDB code: 5DQ8)33. (E) and (F) The predicted binding mode of DC-TEADin1072 with TEAD3-YBD in molecular docking studies.
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