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Fig. 11
In vivo zebrafish screening unravels two inhibitors of angiogenesis. (A–D) Fluorescence microscopy images of representative injected and uninjected control (E) at 72hpf of Tg(kdrl:gfp) embryos. Scale bar, 100 μm. (F) The total length of 10 ISVs per embryo was measured and presented. Both geo35 and SRPIN803 block angiogenesis, with geo35 exhibiting a milder effect than SRPIN803. (G) The percentage of the inhibition of angiogenesis was calculated compared to uninjected sibling controls for each compound. Data are expressed as mean + SEM (n = 30/group). p*** < 0.001.
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