ZFIN Image: Leonidis et al., 2021, Fig. 10

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Figure Caption

Fig. 10

In vivo screening reveals SRPIN803 as a master inhibitor of angiogenesis upon zebrafish treatment assay. (A–E) Fluorescence microscopy images of representative compound treated from 24hpf, and DMSO-treated control 72hpf Tg(kdrl:gfp) embryos. Scale bar, 100 μm. (F) The total length of 10 ISVs per embryo was measured and presented. SRPIN803 shows statistically significant inhibition of ISVs, while the other tested compounds had no effect at the tested concentration. (G) The percentage of inhibition of angiogenesis was calculated compared to DMSO-treated controls for each compound. Data are expressed as mean + SEM (n = 20/group). p*** < 0.001.

Acknowledgments

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