ZFIN Image: Wang et al., 2021, Fig. 5

Image

Figure Caption

Fig. 5

Figure 5. Vascular leakiness was enhanced in DDAH1 transgenic mice but reduced in DDAH1 knockout mice

(A–C) Sex- and age-matched wild type (WT), DDAH1 transgenic (TG) and DDAH1 knockout (KO) mice were subjected to Miles assay. Evans blue (1%) were intravenously injected according to body weight and then intradermal injection of VEGF (50 ng) and PBS was performed. Skin was dissected and imaged (A) and Evans blue was quantified after extraction with formamide and normalized to tissue weight (B). Plasma was also collected at the endpoint to show comparable level of Evans blue in the circulation (C). ∗, p<0.05. Animal numbers in each group are presented in the scatter plot. Data is expressed as mean ± SD. Scale bar, 1 mm, in (A)

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ iScience