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Fig. 2
Identification of DEGs in isl2b:GFP+ RGCs after ONT. (A) Experimental workflow for FACS-isolation of isl2b:GFP+ RGCs. An example FACS plot showing a cell-sorting gate is included. Icons were adapted from BioRender.com. Number of experiments=1. (B) Heatmap showing hierarchical clustering of 308 DEGs at 24 hpi from three biological replicates. (C) Heatmap highlighting DEGs of interest based on known neuroprotective and pro-regenerative functions. Heatmap legends show log2TPM. (D) Pathway enrichment analysis using the KEGG database showing top-3 down- and upregulated pathways after ONT.
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