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Fig. 4
The susceptibility of mutated GI.1 proteases to rupintrivir and compound 4. IC50 values of rupintrivir (A) and compound 4 (B) on the WT or mutant GI proteases. Dose–response inhibition curves of rupintrivir (C) and compound 4 (D) on the WT or mutant GI proteases. Mean values ±SEM are presented, Mann–Whitney test ** p < 0.01, * p < 0.05, ns: not significant.
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