Fig. 6
Morphological features of zebrafish embryos at different developmental stages. (A) At 30 hpf after a 24-h exposure to analogue 9 at concentrations of 300, 600, and 1200 µM, (B) at 54 hpf after a 48-h exposure to analogue 9 at concentrations of 75 and 150 µM, as well as (C) at 30 hpf after a 24-h exposure to analogue 9 at concentrations of 10, 20, and 40 µM. (D) Effects of analogue 9 at concentrations 10, 20, and 40 µM on blood vessel development in transgenic zebrafish, Tg(kdrl:egfp) at 30 hpf, same embryos as in (C). Vasculogenesis and angiogenesis in the trunk region were normal in both the control and analogue 9-treated zebrafish.