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Fig. 3
Model illustrating the Urotensin signaling pathway during body axis development of zebrafish. The beating of ependymal motile cilia drives CSF flow, which mediates the transmission of epinephrine signals and the assembly of Reissner’s fiber. The adrenergic signals activate the expression of Urotensin neuropeptides in the CSF-cNs (Urp1 and Urp2). Finally, the urotensin neuropeptides may further activate the Uts2r3 receptor localized to the dorsal muscle fibers and promote body straightening. Abnormalities in the Urotensin signaling pathway will induce either body curvature in larvae or scoliosis in adult zebrafish