Fig. 11

Perineurial glial bridging is modulated by a positive feedback loop between TGFβ signaling and ctgfa. Summary diagram of our proposed signaling model that drives perineurial glial bridging after injury in control, 10 μM SB431542, and ctgfa^−/− conditions at 0 (top panels) and 8 hpi (bottom panels). Motor axons (magenta), Schwann cells (orange), perineurial glia (light green), ctgfa expressing cells (dark green). The magnified region designates perineurial glial-specific TGFβ signaling. Dotted-lines indicate TGFβ signaling whereas solid lines indicate ctgfa signaling. Red “X”s demonstrate pathways that are inhibited or turned off in either 10 μM SB431542 treatment or ctgfa^−/− larvae.