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Fig. 7
Elimination of Schwann cells immediately prior to injury perturbs perineurial glial bridging. (a,b) Representative images from stills of time-lapse movies of injured 5 or 6 dpf nkx2.2a:megfp;sox10:gal4;UAS:NTR-mch larvae. Dashed circles indicate injury sites. White arrows follow the proximal end and yellow arrows follow the distal end of the perineurial glial bridge (green). Blue arrows indicate phagocytic vesicles. Larvae were treated with either (a) PTU egg water (n = 4 nerves in 3 larvae) or (b) 2 mM ronidazole (RDZ) in PTU egg water (n = 7 nerves in 5 larvae). (c) Quantification of the percentage of the injury gap bridged by perineurial glia (PG) at 6 hpi in larvae treated with either PTU water (green, n = 4 nerves in 3 larvae; mean: 95.25 ± 1.32) or 2 mM RDZ (magenta, n = 7 nerves in 5 larvae; mean: 2.71 ± 1.32) (p < .0001;). Scale bar, 25 μm.
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