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Fig. 7
Neratinib treatment reduces the levels of cytokines IL-6 and KC in BAL in the induction dosing model of lung disease. Cytokines were measured in BAL supernatant by ELISA. Interleukin-6 (IL-6) and KC were reduced in neratinib-treated mice in the induction dosing model (A, B), whereas these were unchanged in the therapeutic dosing model (C, D). Each data point represents data from one mouse; bars show mean ± standard deviation. Unpaired t-tests were used for statistical analysis; p-values were indicated.
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