ZFIN Image: Georgantzoglou et al., 2022, Fig. 6

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Fig. 6

Neutrophils navigate interstitial gradients in vivo through a search and run strategy. Model for neutrophil gradient sensing in vivo. Before encountering the gradient, neutrophils have a pre-established, unspecific polarity, and movement. Upon gradient exposure, neutrophils have a low chance of resolving gradient direction without active actin dynamics, therefore a search phase is required. During this phase, front actin network expansion via Arp2/3 promotes exploration and gradient sampling (illustrated by green spots), culminating in small turns towards the gradient source. Subsequently, cells switch to a running phase, whereby fast actin flows and Myosin-II contractility enforce fast and persistent motion towards the gradient.

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Cell Biol.