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Figure 1
Figure 1. ECG representation and typical recordings; (A), Schematic representation of the interval measurement method. We chose to take the peak of the P and T waves to determine PR and QT intervals respectively to reduce the uncertainty of the measurements when taking before P waves or after T waves; (B), Cartoon representing the different depolarization and repolarization steps of the zebrafish heart cavities. A: atrium, V: ventricle, BA: bulbus arteriosus; (C–E), Schematic representation of the electrode positioning in the different configurations and representative traces; (C), Unexposed heart; (D), Exposed heart; (E), Extracted heart, * indicates putative P wave. Traces show three consecutive ECG complexes after application of a 50 Hz low-pass filter.
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