Image
Figure Caption

Figure 5—figure supplement 2.

The installation of an additional PTC at tnnt2-W201X with evoBE4max leads to a recapitulation of the silent heart phenotype.

(a) O. latipes tnnt2a coding region with annotation of all sgRNAs (a’) targeting tnnt2a used in this study. (b) Overview of phenotypic categories and the quantification of phenotypic outcomes following base editing F0 tnnt2a base editing experiments (c). (d) Representative Sanger sequencing reads. (e) Summary of C-to-T or A-to-G conversion efficiencies.

Acknowledgments
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