ZFIN Image: Boddy et al., 2022, Figure 3

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Figure Caption

Figure 3

Metabolites identified in an unbiased screen are significant in multiple robust MR measures. (A–C) Scatter plots demonstrating the correlation between genetic liability to serum estrone-3-sulphate (IVW P = 6.58e−05, beta = −0.03, se = 0.008) (A), bradykinin (IVW P = 8.07e-05, beta = −0.05, se = 0.01) (B), and isoleucine (IVW P = 1.29e−04, beta = 0.05, se = 0.01) (C), with genetic liability to ALS. Points indicate effect size (β) and standard errors for each SNP-outcome relationship. (D) Robust MR measures and sensitivity analyses for each MR analysis.

Acknowledgments

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