ZFIN Image: Baek et al., 2022, Figure 6

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Figure Caption

Figure 6

WSS-responsive Notch-ephrinb2 pathway regulates arterial network formation. (A) Injection of ephrinb2 MO (0.5-1mM) diminished flt1⁺ in the amputated site (white arrowheads) to attenuate loop formation at 4 dpa (white arrow). Transient overexpression of ephrinb2 mRNA promoted flt1⁺ network formation in the amputated site (white arrowheads) and restored DAPT and DN-Notch1b mRNA-impaired flt1⁺ regeneration (white arrow) (n = 20 per group). Scale bar: 20 μm. (B) Schematic representations of ephrinb2-dependent flt1⁺ and flt14⁺ regeneration. Black arrowheads depict regenerated flt1⁺ (Red) and flt4⁺ (Blue) in response to differential ephrinb2 expressions.

Acknowledgments

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