FIGURE 7

FIGURE 7

Early wound healing stage of brain regeneration is more similar to LGG and GBM than the proliferation and differentiation stages. (A,B) GOChord plots show log₂ fold changes of the genes annotated in selected KEGG pathways (A) “Glioma” and “Pathways in cancer” and (B) “Wnt”, “p53”, “Jak-STAT”, “Notch” and “Apoptosis” for three stages of the zebrafish brain regeneration and two types of human brain cancers. The genes are linked to their assigned pathways by ribbons and ordered according to their log₂ fold change values from high to low regulation, represented by a color gradient from blue to red, respectively. log₂ fold changes are shown from the outer to the inner annulus in the following order: 1, 3, 14 dpl, LGG and GBM. An asterisk was appended to human genes associated as orthologs to several zebrafish genes in the list. dpl: days post-lesion, LGG: low-grade glioma, GBM: glioblastoma.