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Figure 10
Antiseizure activity analysis of plinabulin in the mouse 6 Hz psychomotor seizure model. Drug-resistant psychomotor seizures were induced by electrical stimulation (6 Hz, 0.2 ms rectangular pulse width, 3 s duration, 44 mA) through the cornea, 30 min after intraperitoneal injection of vehicle (VHC, n = 11), positive control valproate (n = 6), or plinabulin (n = 8–9). Mean seizure durations (±SD) are depicted. Statistical analysis: one-way ANOVA with Dunnett’s multiple comparison test (GraphPad Prism 9). Significance levels: * p ≤ 0.05; ** p ≤ 0.01; *** p ≤ 0.001.
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