ZFIN Image: Dal et al., 2021, Fig. 6.

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Figure Caption

Fig. 6. Evaluation of the in vivo efficacy of PM-formulated nNF derivatives in the zebrafish TB model. Zebrafish embryos were infected with Mm-dsRed and treated with different doses of the PM-formulated nNF derivates C7, C11, C12 or PM-formulated RIF by intravenous injection. (A) Representative images of Mm-infected embryos treated with different doses of PM-C7 at 4 dpt. Scale bar: 500 μm. (B) Quantification of bacterial burden by FPC at 4 dpt in embryos treated with the indicated doses of the PM-formulated compounds or RIF. FPC values of individual embryos were normalized to the untreated control (ctrl) group and results are presented as mean±s.d. Results are pooled from at least three independent experiments. The mean values of each group are displayed above the columns. na, not applicable. **P<0.01, ***P<0.001 (non-parametric Kruskal–Wallis H test followed by post-hoc analysis using Dunn's multiple comparisons test).

Acknowledgments

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