ZFIN Image: Allen et al., 2021, Figure 4

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Figure 4

Versican-mediated extracellular matrix organization is enriched in extravasated circulating tumor cells. (A) Versican is commonly upregulated in both cell lines and interacts with a core subset of the extracellular matrix organization pathway. Yellow nodes indicate proteins that share at least one interaction with versican. (B) Ranking of top nodes based on neighborhood connectivity, (C) betweenness centrality, and (D) number of edges in the extracellular matrix remodeling pathway. Prognostic value of VCAN for (E) metastasis-free survival and (F) overall survival in osteosarcoma patients.

Acknowledgments

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