ZFIN Image: Ross et al., 2021, Fig. 4

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Figure Caption

Fig. 4 Visualization and analysis of tet1/2/3 KO RRBS data. (a) Left panel: IGV visualization of BAM files in bisulfite mode (CG) over a phylo-DMR (phylotypic stage enhancer) region. Red = methylated cytosine, blue = unmethylated cytosine. Grey boxes represent single reads. Right panel: IGV visualization of BigWig files. Blue bars represent methylation level (mCG/CG). (b) Global mCG/CG levels of two biological replicates of uninjected (wt) and injected (tet1/2/3 KO) 24hpf F0 zebrafish. Methylation values correspond to average mCG/CG level in genomic bins (150 bp). (c) PhyloDMR mCG/CG levels of two biological replicates of uninjected (wt) and injected (tet1/2/3 KO) 24 hpf F0 zebrafish. (d) Heatmap showing locus-specific mCG/CG levels in phyloDMRs

Acknowledgments

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