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Figure 6
Molecular model of α-MSH and zebrafish MC1R complex. The MC1R (carton representation) binds α-MSH in a cavity between the extracellular loops (ELs) and the transmembrane helices (TMs). Visualized are amino acids (sticks) covering the ligand binding site and are highly important for ligand and co-factor calcium (Ca2+) binding. All α-MSH ligand variants from different species share a conserved core motif (HRFW) involved in receptor-ligand contacts. The α-MSH C-terminus with position 13 (M13) is not in direct contact with the receptor as supposed by MC4R/α-MSH or MC1R/α-MSH complexes.
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Full text @ Int. J. Mol. Sci.