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Figure 1
Characteristic features of zebrafish melanophore physiology. (a) High-resolution magnification of larval melanophores before and after treatment with the aggregating agent. Numbers (1, 2, 3) indicate individual melanophores two minutes after melatonin treatment. Schematic describes movement of melanosomes during aggregation process. Scale bars: 100 µm. (b) Diagram of melanophore pigment cell showing major intracellular events following receptor-ligand binding of aggregating/dispersive agents. (c) Schematic showing POMC gene product and derivative molecules generated by post-translational processing. Abbreviations: mch: melanin-concentrating hormone, npp: N-terminal peptide of proopiomelanocortin, clip: corticotropin-like intermediate peptide, lph: lipotropin.