Figure 4

Figure 4. (A) UAZ enhance pancreatic b-cell viability when RINm5F cells were incubated in RPMI1640 medium containing glucose at 30 mM with or without various concentrations of (UAZ; 10, 25, and 50 µg/mL) for 48 h; (B) UAZ improved high glucose impaired insulin secretion; (C) Effect of UAZ on intracellular levels of reactive oxygen species (ROS) in high glucose-treated RINm5F cells; (D) TBARS generation in high glucose-treated INS-1 pancreaticβ-cells. The use of 5.5 mM glucose was representative of normal glucose conditions and the 30 mM glucose treatments represent high glucose conditions. Data are expressed as the mean ± SD, * p < 0.05, ** p < 0.01, and *** p < 0.001.