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Fig. 4 Overall transcriptome dysregulation at the level of KEGG biochemical pathways was normalized by Glu + NA + NAC pairwise combinatorial therapies in C. elegans gas-1(fc21) worms. Parametric analyses of gene set enrichment (PAGE) scores are shown for selected KEGG pathways that showed significant dysregulation in gas-1(fc21) worms compared to N2 (WT) at baseline, and/or showed significant modulation in gas-1(fc21) worms when treated with Glu + NA + NAC triple combination therapy, or its individual or pairwise components, for 24 h at the young adult stage. For each comparison, the increased or decreased expression is shown for the second group named in the title relative to the first group. The greatest overall normalization of dysregulated pathway-level expression in gas-1(fc21) worms occurred with the 3 pairwise drug comparisons studied, * P < 0.05, **, P < 0.01, and ***, P < 0.001 for each two-way comparison, as shown. Additional transcriptome results are shown in Supplementary Material, Fig. S5.